Base64 and URL encoding (percent-encoding) are both encodings, but they exist for opposite reasons. Base64 turns binary data into a compact ASCII string so it can travel through text-only channels. URL encoding escapes unsafe characters so a value can sit inside a URL without breaking it.
People confuse them because both produce funny-looking strings, yet swapping one for the other causes bugs. Base64 makes data bigger and safe for transport; URL encoding makes specific characters safe for a specific context.
At a glance
Aspect
Base64
URL Encoding
Purpose
Binary to text-safe ASCII
Escape unsafe URL characters
Output
A-Z, a-z, 0-9, +, /, =
%XX hex escapes for reserved chars
Size effect
Grows ~33%
Grows only for escaped chars
Typical use
Images in CSS, email attachments, tokens
Query strings, form values
Reversible
Yes
Yes
When to use Base64
You need to embed binary (images, files) inside text like JSON or CSS.
You're encoding credentials or tokens for headers.
A channel only accepts printable ASCII.
When to use URL Encoding
You're placing a value into a URL query string or path.
Your value contains spaces, ampersands, or other reserved characters.
You want minimal size overhead for mostly-safe text.
Verdict
They aren't alternatives — pick by context. Use Base64 to carry binary through text pipes; use URL encoding to keep values from breaking URLs. Note there's also a "base64url" variant that swaps + and / for URL-safe characters, which is what you want when Base64 data must live inside a URL.